CAR-T cells in glioblastoma
Comprehensive Brain Tumor Center
Comprehensive Brain Tumor Center
Overview
The Comprehensive Brain Tumor Center at Lifespan combines multidisciplinary clinical care with cutting-edge basic research in the diagnosis and treatment of intracranial benign and malignant tumors. Our team of specialized neurosurgeons, neuro-oncologists, and radiation oncologists share deep expertise in the treatment of acoustic neuromas, pituitary tumors, meningiomas, metastatic disease, gliomas and lymphomas.
We offer a range of treatments including surgery, chemotherapy, and advanced radiation therapies, such as Intensity-Modulated Radiotherapy (IMRT), Gamma Knife and CyberKnife. Our division has a dedicated laboratory for brain tumor research, collaborating with leading academic institutions to develop novel treatments for our patients.
Specialty Team
Neurosurgery Department Team
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Clark C. Chen, MD, PhD
Professor of Neurosurgery, Director, Brain Tumor Program, Co-Director, Stereotactic Radiosurgery Program -
Deus J. Cielo, MD
Associate Professor of Neurosurgery, Vice-Chair for Diversity, Inclusion and Equity, Director, Peripheral Nerve Surgery Division, Co – Director of Stereotactic Radiosurgery Program, Director, Memorial Hospital Neurosurgery Program -
Curtis E. Doberstein, MD
Professor of Neurosurgery, Executive Vice Chair, Clinical Operations, Director, Cerebrovascular and Skull-base Surgery Division, Director, Neurosurgery Residency Training Program -
Prakash Sampath, MD
Associate Professor of Neurosurgery, Director, Robotic Neurosurgery, Director, Brain Tumor Immunotherapy Program, Director, Neurosurgery at Roger Williams Medical Center -
Konstantina A. Svokos, DO, MS
Associate Professor of Neurosurgery and Pediatrics, Director of Fetal Neurosurgery, Co-Director, Neuroplastics, Co-Director, Center for Surgical Treatment of the Developing Brain and Spine, Pediatric Neurosurgeon
Neuro-oncologists
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Heinrich Elinzano, MD
Associate Professor of Neurology and Medicine, Clinician Educator, Co-Director, Brain Cancer Committee, Co-Director, Brown University Oncology Research Group, Neuro-Oncology Medical Lead, Lifespan Cancer Institute -
Eric T. Wong, MD
Professor of Neurology, Medicine, Neurosurgery & Radiation Oncology, Director of Medical Neuro-Oncology
Pathologists
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John E. Donahue, MD
Associate Professor of Pathology and Laboratory Medicine -
Ivana DeLalle, MD, PhD
Professor of Pathology and Laboratory Medicine
Radiation Oncologists
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Jaroslaw T. Hepel, MD
Associate Professor of Radiation Oncology and Neurosurgery, Director of Stereotactic Radiosurgery at Rhode Island Hospital -
Kara Leonard, MD
Assistant Professor of Radiation Oncology, Adjunct Assistant Professor of Radiation Oncology, Tufts University School of Medicine, Associate Program Director, Radiation Oncology Residency, Tufts University School of Medicine
Conditions We Treat
Benign tumors:
acoustic neuromas (vestibular schwannoma), pituitary tumors (or pituitary adenoma), meningiomas
Malignant tumors:
metastatic cancers, gliomas, lymphomas, chordomas, chondrosarcomas, esthesioneuroblastoma
Research
Molecular Neuroscience and Neuro-Oncology Laboratory
Neurosurgery Department
Glioma cell migration
Glioblastoma stem cells
RNA regulation of glioblastoma
2D and 3D co-culture models
The Brain Tumor Immunotherapy Research Laboratory
Robert Langer, PhD (MIT)
Hydrogels and drug delivery
Irving Weinberg, MD, PhD
Advanced MRI and magnetic nanoparticles in drug delivery
Bodour Salhia, PhD (USC)
Epigenetics of metastasis
Jack Elias, MD (Brown University)
The role of chitosome and inflammation in cancer
Ou Chen, Phd (Brown University)
Development of nanoparticles for drug delivery and tumor detection department of nanoparticles for glioma discovery / therapy
Jonghwan Lee, Phd (Brown Univeristy)
optical coherence tomography (OCT) in glioma
Technology
CyberKnife Robotic Radiosurgery System
Gamma Knife Radiosurgery System
TrueBeam Radiotherapy System