Lateral lumbar interbody fusion (LLIF) is a surgery for spinal fusion, but it can lead to plexopathies (nerve issues). A study on 127 patients who underwent LLIF found that around 37.8% developed sensory or motor plexopathies. Most cases (64.6%) resolved within about 402 days. Ipsilateral plexopathies (on the same side as the surgery) were more common. Persistent symptoms were linked to the number of fused levels and surgical duration. Unresolved neuromonitoring alerts during surgery increased the risk of developing plexopathies. This research highlights the common occurrence of plexopathies after LLIF and factors affecting their persistence.