Publication
Lauro PM
, Lee S, Amaya DE, Liu DD, Akbar U, Asaad WF. Elife. 2023 May 30;12:e84135. doi: 10.7554/eLife.84135. PMID: 37249217; PMCID: PMC10264071.
Parkinson’s disease (PD) has varying motor symptoms like tremor and bradykinesia. Researchers studied brain activity in PD patients during motor tasks to decode these symptoms and periods of better movement control. They used microelectrode and electrocorticography recordings and found that tremor and bradykinesia have different brain patterns, and effective motor control has unique features. Cortical decoding was more effective than subcortical, and within the subthalamic nucleus, different subregions decoded tremor and bradykinesia. This research could lead to better treatment strategies for PD by using neurophysiological insights.