Obsessive-compulsive disorder (OCD) affects a significant portion of the population, and some patients don’t respond well to conventional treatments. Gamma knife capsulotomy (GKC) is an option for such cases. Researchers studied patients who received GKC targeting a brain region. They found that lesions in specific locations within this region were associated with the most significant reduction in OCD symptoms. Lesions toward the back and top of this area were particularly effective. The study indicates GKC remains effective for refractory OCD, and targeting specific regions might optimize treatment outcomes. Further research is needed to better understand individual variations and refine targeting methods.